Unraveling the function of supersulfides in regulating mitochondrial perform and longevity

Supersulfides, lots of that are produced by cysteinyl-tRNA synthetase (CARS), are important compounds throughout many various lifeforms. Nevertheless, the exact physiological roles of CARS-produced supersulfide are unclear. Now, utilizing a strategically engineered yeast mutant with a poor CARS gene, researchers from Japan have proven that supersulfides management cell longevity by mediating mitochondrial vitality metabolism and regulating protein high quality.